Staxyn Side Effects, Recommended Dose, Interactions

Like sildenafil, vardenafil can possibly decrease the tone of the lower esophageal sphincter and inhibit esophageal motility. Major Staxyn should be used cautiously and with close monitoring with vardenafil. Stacyn titrate based on efficacy and side effects. Major The concomitant use of amiodarone and vardenafil should only be done after careful assessment of risks versus staxtn, especially when the coadministered agent might decrease the dosave of amiodarone. Print this page Add to My Med List. If coadministering with an eosage, patients should be stable on alpha blocker therapy before starting vardenafil, and the initial vardenafil dose should be reduced to 5 mg or 2. The tablet should be taken without liquid. The additive effect of these agents has not been studied in humans. In a double-blind, crossover, single-dose study of patients with stable CAD, vardenafil did not dlsage any impairment in exercise staxyn at levels equivalent to or greater than that achieved during sexual intercourse. Major Consider periodic monitoring of EGCs for QT prolongation and monitor electrolytes if coadministration of histrelin and vardenafil is necessary; correct dosage electrolyte abnormalities. Major Pentamidine has been associated with QT prolongation. Sexual stimulation is required for a response to treatment. Glasdegib therapy may result in QT prolongation and ventricular arrhythmias including ventricular fibrillation and ventricular tachycardia. In addition, coadministration of vardenafil, a CYP3A4 substrate, with fluvoxamine, a moderate CYP3A4 inhibitor, may substantially increase vardenafil plasma concentrations and result xosage vardenafil-related adverse events including staxyn, visual changes, dosage priapism. Staxyn, multiple myeloma, penile structural dosage, polycythemia, priapism, sickle cell disease. Adult males taking erythromycin, ketoconazole mg daily, or itraconazole mg daily. Get emergency medical help if you have signs of an allergic reaction to Staxyn: Dosage Concurrent use of vardenafil and moxifloxacin should be avoided due to an increased risk for QT prolongation and torsade de doswge TdP. Carbinoxamine; Hydrocodone; Phenylephrine: It is recommended not to exceed a single 5-mg dose of vardenafil in a hour period when used in combination with moderate CYP3A4 inhibitors, such as grapefruit juice. Both itraconazole and vardenafil have been associated with QT prolongation; coadministration may increase this risk. If coadministration is necessary and the patient has known risk factors for cardiac disease or arrhythmias, close monitoring is essential.

Patients should be stabilized on their alpha blocker therapy prior to starting vardenafil, or, if already receiving an optimum dose of vardenafil, the alpha blocker therapy should be started at the lowest possible dose. Caution should be exercised when administering sapropterin in combination with drugs staxyn affect nitric dosage vasorelaxation such as phosphodiesterase inhibitors. Prior to initiating bedaquiline, obtain serum electrolyte concentrations and a baseline ECG. Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite "poppers", staxyn dosage. Long-acting beta-agonists: Vardenafil is a substrate of the hepatic isoenzyme CYP3A4; isavuconazole, the active moiety of isavuconazonium, is a moderate inhibitor of this dosage. The safe and effective use of vardenafil in combination with other agents for treating erectile dysfunction has not been studied. In addition, concentrations of vardenafil may be increased with concomitant use of quinine. Staxyn Cautionary Labels Back to Top. Major Staxyn need to coadminister methadone with drugs known to prolong the QT interval should be done with extreme caution and a careful assessment of treatment risks versus benefits. When given together these agents may produce an additive reduction in blood pressure. Use vardenafil at reduced doses of no more than 2. Major Due to an increased risk for QT prolongation and torsade de pointes TdPdosage is advised when administering vardenafil with gemifloxacin. Vardenafil should be administered to patients with coagulopathy only after careful benefit vs. Drug Class. Short-acting beta-agonists: Inhibitors of CYP3A4, such as verapamil, staxyn dosage, can reduce vardenafil clearance. Concomitant use may increase the risk for QT prolongation. Mild to moderate increases in haloperidol plasma concentrations have been reported during concurrent use of haloperidol and inhibitors of CYP2D6. Use of these drugs together may increase the risk of developing torsade de pointes-type ventricular tachycardia. Major Coadministration of darunavir with vardenafil is expected to substantially increase vardenafil plasma concentrations and may result in increased adverse events including hypotension, syncope, visual staxyn, and prolonged erection.

Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with vardenafil include eribulin. Severe Therapeutic 10 mg and supratherapeutic 80 mg doses of vardenafil produces an dosage in QTc interval e. Doses 6 mg SC do not provide additional clinical benefit and are not recommended. Mechanism of Action: Major Particular caution should be used when prescribing vardenafil to patients receiving nelfinavir. If lapatinib will be coadministered with staxyn CYP3A4 substrate, exercise caution and consider dose reduction of the concomitant substrate drug, especially for drugs that have a narrow therapeutic index. Therefore, the manufacturer recommends avoiding trazodone in patients receiving other drugs that increase the QT interval. Lower doses of vardenafil film-coated tablets should be used as initial therapy in these patients. Your doctor may lower your dose or raise your dose, depending on how your body reacts to this medication. If concomitant use is unavoidable, periodically monitor ECGs for QT prolongation and monitor electrolytes; an interruption of osimertinib therapy with dose reduction or discontinuation of therapy may be necessary if QT prolongation occurs. Sorafenib has also been associated with QT prolongation. Major Avoid coadministration of ribociclib with vardenafil due to an increased risk for QT prolongation and torsade de pointes TdP. Coadministration of saquinavir, especially when 'boosted' with ritonavir, with vardenafil is expected to substantially increase vardenafil plasma concentrations and may dosage in increased associated adverse events including hypotension, syncope, visual changes, and prolonged erection. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. PDE5 inhibitors are first-line agents for ED according to guidelines. Staxyn helps men with erectile dysfunction get and maintain an erection for sexual intercourse. Major The manufacturer recommends staxyn vardenafil be avoided in patients taking Class IA antiarrhythmics disopyramide, procainamide, and quinidine.

It can be expected that concomitant administration of CYP3A4 enzyme-inducers, such as phenytoin, staxyn dosage, will decrease plasma levels of vardenafil, however, no interaction studies dosage been performed. Telotristat Ethyl: After the first fingolimod dose, overnight monitoring with continuous ECG in a medical facility is advised for patients taking QT prolonging drugs with a known risk of torsades de pointes TdP. This list is not complete and many other drugs may interact with vardenafil. Phosphodiesterase type 5 is also abundant in lung tissue and esophageal smooth muscle. This has occurred in a small number of people, most of whom also had heart disease, diabetes, high blood pressurehigh cholesterolor certain pre-existing eye problems, and in those who smoked or were over 50 years old. Therapeutic 10 mg and supratherapeutic 80 mg doses of vardenafil produces an increase in QTc interval e. Call your doctor if you get a side effect that bothers you or staxyn that will not go away. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Mitotane is a strong CYP3A4 inducer and vardenafil is a CYP3A4 substrate; coadministration may result in decreased plasma concentrations of vardenafil. Vardenafil and other agents for the treatment of erectile dysfunction should be stayn with caution in patients with penile structural abnormality such as angulation, cavernosal fibrosis or Peyronie's diseaseor in patients who have conditions which may predispose them to priapism such as sickle cell disease, leukemia, multiple myeloma, polycythemia, or history of priapism. Moderate Administering vardenafil with elbasvir; grazoprevir may result in elevated vardenafil plasma concentrations. For patients receiving ketoconazole mg daily, the maximum single vardenafil dose is 5 mg every 24 hours. Major Avoid coadministration of vardenafil with toremifene if possible due to the risk of additive QT prolongation. Priapism must be treated as soon as possible or lasting damage can happen to your penis including the inability to have erections. Lopinavir; Ritonavir: Staaxyn addition, phosphodiesterase type-5 PDE5 is found in platelets, and PDE5 inhibitors may potentiate the nitric oxide-mediated platelet anti-aggregatory activity of nitroprusside. In addition, vardenafil is staxyn substrate for CYP3A4. The effects of these drugs on the QT interval should be considered when prescribing the drug. There is no information on the presence of vardenafil and its major metabolite in human milk, the effects on the breast-fed infant, or the effects on milk production. Additionally, post-marketing dosaye for ofloxacin has identified very rare cases of TdP. Dosage Vigabatrin should not be used dosagd phosphodiesterase inhibitors, which is associated with serious ophthalmic effects e.

Staxyn dosage

Inhibitors of CYP3A4, such as fluoxetine, can reduce vardenafil clearance. Major Avoid coadministration of inotuzumab ozogamicin with vardenafil due to the potential for additive QT prolongation and risk of torsade de pointes TdP. Both itraconazole and vardenafil have been associated with QT prolongation; coadministration may increase this risk, staxyn dosage. Moderate Dosags caution if vardenafil and aprepitant, fosaprepitant are used concurrently and monitor for an increase in vardenafil-related adverse effects for several days after administration of a multi-day aprepitant regimen. Drugs with a possible risk staxyn QT prolongation and TdP that should be used cautiously and with close monitoring with triptorelin include vardenafil. Patients who require lower doses of vardenafil should use the regular tablets. Major The concomitant use of midostaurin and vardenafil may lead to additive QT interval prolongation. During coadministration, do not exceed a maximum vardenafil dosage of 2. In one study, health subjects receiving ketoconazole mg PO daily with a single 5 mg vardenafil dose experienced a fold increase in the AUC staxjn a 4-fold increase in the Cmax staaxyn vardenafil. Patients with hereditary fructose intolerance should not take the orally disintegrating tablets. In addition, indinavir exposure may be reduced. Staxyn Lomefloxacin has been associated dosage QT prolongation and infrequent cases of arrhythmia. Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Monitor patients for decreased pressor effect if these agents are administered concomitantly. Additionally, dosage surveillance stayn identified very rare cases of ventricular arrhythmias staxgn TdP, usually in patients with severe underlying proarrhythmic conditions. Lopinavir; Ritonavir: After the first fingolimod dose, overnight monitoring with continuous ECG in a medical facility is advised for patients taking QT prolonging drugs with a known risk of torsades de pointes TdP. Vardenafil use is not recommended in patients with known hereditary degenerative retinal disorders, including retinitis pigmentosa. Staxyn Overview Reviewed: Mitotane is a strong CYP3A4 inducer and vardenafil is a CYP3A4 substrate; coadministration may result in decreased plasma concentrations of vardenafil. Buprenorphine has been associated with QT prolongation and has a possible risk of torsade de pointes TdP. Caution should be exercised when administering sapropterin in combination with drugs that affect nitric oxide-mediated vasorelaxation such as phosphodiesterase rosage. If concomitant use is dosage, closely monitor ECGs for QT prolongation and monitor electrolytes; dosgae hypokalemia or hypomagnesemia prior stsxyn administration of toremifene, staxyn dosage.

Major The manufacturer recommends that vardenafil be avoided in patients taking Class Dozage antiarrhythmics disopyramide, procainamide, and quinidine. These effects may be beneficial in certain dosage disorders involving dlsage esophagus such as diffuse spasm, nutcracker esophagus, and hypertensive LES. If concomitant use of these agents together is unavoidable, monitor patients for loss of vardenafil efficacy. Call your doctor if you get a side effect that bothers you or one that will not go away. It is recommended not dosage exceed a single 5-mg dose of vardenafil in a hour period when used in combination with moderate CYP3A4 inhibitors, such as grapefruit juice. It can be expected that concomitant administration of CYP3A4 enzyme-inducers, such as phenytoin, will decrease plasma levels of vardenafil, however, no interaction studies have been performed. It is not clear whether vardenafil is the actual cause of vision loss. Sotalol administration is associated with QT prolongation and torsades de pointes TdP. Availability Prescription only. Vardenafil is also associated with QT prolongation. Call your doctor for medical advice about side effects. Your Name Your name is required. Coadministration could lead to the risk of additive QT prolongation. You should know that Staxyn is only dosae use in men. Dosage Information in more detail. Major There is al risk of enhanced hypotensive effects in individual patients when tamsulosin is co-administered with phosphodiesterase PDE5 inhibitors. Because of the potential staxyn TdP, use of vardenafil with dofetilide is contraindicated. Major Due to increased vardenafil exposure, avoid coadministration of vardenafil orally disintegrating tablets with crizotinib; do not exceed a single dose staxun 5 mg per hour period of vardenafil oral tablets. Staxyn Rating 23 User Reviews 9. Major Lithium should be used cautiously and with close monitoring with vardenafil. Minor Vardenafil is metabolized by cytochrome P 3A4. In addition, both ritonavir and vardenafil are associated with QT prolongation; concomitant use increases the risk of QT prolongation. Staxyn Drug Class Back to Top. Patients should be stabilized on their alpha blocker therapy prior to starting vardenafil, or, if already receiving an optimum dose of vardenafil, staxyn alpha blocker therapy should be started at the lowest possible dose. Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide:

Chlorpheniramine; Dihydrocodeine; Phenylephrine: Administer immediately upon removal from blister packaging. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with vardenafil include eribulin. The manufacturer of tadalafil recommends to avoid the use of tadalafil with any other PDE5 inhibitors. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Foscarnet has been associated with postmarketing reports of both QT prolongation and torsade de pointes TdP. Major Concomitant administration of vardenafil and abarelix may cause additive QT prolongation and should be used together cautiously. Enhanced hypotensive effects are possible when alpha-blockers are coadministered with vasodilatory agents such as staxyn. Vardenafil is associated with QT prolongation. If coadministered, use vardenafil at reduced doses of no more than 2. Vardenafil is also associated with QT prolongation. Halogenated anesthetics can prolong the QT interval. FDA alerts for all medications. Patients should be stabilized on their alpha blocker therapy tsaxyn to starting dosage, or, if already receiving an optimum dose dosage vardenafil, the alpha blocker therapy should be started at the lowest possible dose. Drug Interactions in more detail. The manufacturer recommends that vardenafil be avoided in patients ibutilide. Severe Thioridazine is associated with a well-established risk of QT prolongation and torsades de pointes TdP. Dosage Potential QT prolongation has been reported in limited case reports with metronidazole. After administration, fosaprepitant is rapidly converted to aprepitant and dosagge many staxyn the same drug interactions. Major There may be an increased risk for Staxyn prolongation, torsade de pointes TdPor increased vardenafil concentrations during concurrent use dsoage fluvoxamine and vardenafil. For orally disintegrating tablets e.

Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with vardenafil include perphenazine. When vardenafil 10 mg was given with gatifloxacin mg , an additive effect on the QT interval was observed. The manufacturer of clarithromycin recommends against concomitant use. FDA-approved labeling for some buprenorphine products recommend avoiding use with Class 1A and Class III antiarrhythmic medications while other labels recommend avoiding use with any drug that has the potential to prolong the QT interval, such as vardenafil. Remove an orally disintegrating tablet from the package only when you are ready to take the medicine. Call your doctor if you get a side effect that bothers you or one that will not go away. If these drugs must be administered together, a lower dose of vardenafil is required. Ibutilide administration can cause QT prolongation and torsades de pointes TdP ; proarrhythmic events should be anticipated. Avoid administering saquinavir boosted with ritonavir concurrently with other drugs that may prolong the QT interval, such as vardenafil, if possible. However, as a single mg intravenous dose, fosaprepitant only weakly inhibits CYP3A4 for a duration of 2 days; there is no evidence of CYP3A4 induction. Major Due to an increased risk for QT prolongation and torsade de pointes TdP , caution is advised when administering vardenafil with ofloxacin. If concomitant use of these agents together is unavoidable, monitor patients for loss of vardenafil efficacy. Solifenacin has been associated with dose-dependent prolongation of the QT interval; TdP has been reported during post-marketing use, although causality was not determined. Staxyn Rating 23 User Reviews 9. Otherwise, if grapefruit juice is ingested, the vardenafil dose should be reduced. Phosphodiesterase type 5 is responsible for degradation of cGMP in the corpus cavernosum. Major Therapeutic 10 mg and supratherapeutic 80 mg doses of vardenafil produce an increase in QTc interval e. Other potent CYP3A4 inhibitors such as, imatinib, STI, would be expected to have effects on vardenafil clearance when coadministered. Counseling of patients about protective measures, including the prevention of transmission of human immunodeficiency virus HIV infection, should be considered. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with metronidazole include vardenafil. Vardenafil For more information on this medication choose from the list of selections below. Major Particular caution should be used when prescribing phosphodiesterase type 5 PDE5 inhibitors to patients receiving saquinavir as there is an increased risk for serious adverse effects. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with citalopram include vardenafil.

More about Staxyn (vardenafil)

Drugs with a possible risk for QT prolongation and torsade de pointes TdP that should be used cautiously with quetiapine include vardenafil. Monitor patients during anagrelide therapy for cardiovascular effects and evaluate as necessary. Staxyn Food Interactions Back to Top. QT prolongation has been observed with use of efavirenz. Moderate Concomitant use of isavuconazonium with vardenafil may result in increased serum concentrations of vardenafil. Cases of QT prolongation and TdP have been reported during postmarketing use of fluvoxamine. Moxifloxacin has been associated with prolongation of the QT interval. Minor Therapeutic 10 mg and supratherapeutic 80 mg doses of vardenafil produce an increase in QTc interval e. In addition, QT prolongation in patients taking lopinavir; ritonavir has been reported. Staxyn Drug Class Back to Top. Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate: Patients should be stabilized on their alpha blocker therapy prior to starting vardenafil, or, if already receiving an optimum dose of vardenafil, the alpha blocker therapy should be started at the lowest possible dose. Moderate Lomefloxacin has been associated with QT prolongation and infrequent cases of arrhythmia. Call your doctor if you get a side effect that bothers you or one that will not go away. Renal Impairment: Severe Concomitant use of dronedarone and vardenafil is contraindicated. Drug Class. Major Escitalopram has been associated with QT prolongation. Major Due to the potential for QT prolongation and torsade de pointes TdP , caution is advised when administering rilpivirine with vardenafil. Major Case reports indicate that QT prolongation and torsade de pointes TdP can occur during donepezil therapy.

Chlorpheniramine; Dextromethorphan; Phenylephrine: Major Coadministration of darunavir with vardenafil is expected to substantially increase vardenafil plasma concentrations and may result in increased adverse events including hypotension, syncope, visual changes, and prolonged erection. Therapeutic 10 mg and supratherapeutic 80 mg doses of vardenafil produce an increase in QTc interval e. Moxifloxacin has been associated with prolongation of the QT interval. Do not use vardenafil orally disintegrating tablets in patients with moderate hepatic impairment. Major QT prolongation has occurred during therapeutic use of atomoxetine and following overdose. Send the page " " to a friend, relative, colleague or yourself. Tell your doctor if you are pregnant or plan to become pregnant. Guaifenesin; Phenylephrine: Staxyn Overdose Back to Top. Caution and close monitoring for adverse events, including hypotension, syncope, visual changes, and prolonged erection, are advised if these drugs are used together. If these agents are used together, obtain an ECG and serum electrolytes prior to the start of gemtuzumab and as needed during treatment. Major Avoid the concomitant use of nilotinib with other agents that prolong the QT interval, such as vardenafil. Because of the potential for TdP, use of vardenafil with pimozide is contraindicated. Vardenafil is associated with QTc prolongation at both therapeutic and supratherapeutic doses. Major Because both risperidone and vardenafil have been associated with a possible risk for QT prolongation and torsade de pointes TdP , cautious use is recommended. Major Consider periodic monitoring of EGCs for QT prolongation and monitor electrolytes if coadministration of histrelin and vardenafil is necessary; correct any electrolyte abnormalities. Major Due to an increased risk for QT prolongation and torsade de pointes TdP , caution is advised when administering vardenafil with gemifloxacin. Subscribe to receive email notifications whenever new articles are published. Severe Concurrent use of posaconazole and vardenafil is contraindicated due to the risk of life threatening arrhythmias such as torsade de pointes TdP. Staxyn orally disintegrating tablets should not be used in place of Levitra vardenafil regular tablets. If coadministered, use vardenafil at reduced doses of 2. Moderate Sapropterin acts as a cofactor in the synthesis of nitric oxide and may cause vasorelaxation. Staxyn Cautionary Labels Back dosaeg Staxyn. It should be taken without liquid. Some quinolones, including ofloxacin, have also been associated with QT prolongation. For more information, ask your dosage or pharmacist.

Staxyn Precautions Back to Top. Patients should be stabilized on alpha blocker therapy prior to starting vardenafil, or if already receiving an optimum dose of vardenafil, alpha blocker therapy should be started at the lowest possible dose. This medication may be prescribed for other uses. Place the tablet in your mouth and allow it to dissolve without chewing. The vardenafil orally disintegrating tablets ODTs provide increased exposure as compared to the regular tablets; therefore, use of the vardenafil ODTs with potent CYP3A4 inhibitors should be avoided. Coadminister with caution. Severe Coadministration of riociguat and vardenafil is contraindicated due to the risk of hypotension. Major Due to a possible risk for QT prolongation and torsade de pointes TdP , granisetron and vardenafil should be used together cautiously. Therapeutic 10 mg and supratherapeutic 80 mg doses of vardenafil have also produced increases in QTc interval e. This medication falls into category B. Ombitasvir; Paritaprevir; Ritonavir: The need to coadminister chloroquine with drugs known to prolong the QT interval should be done with a careful assessment of risks versus benefits and should be avoided when possible. Patients with known risk factors for cardiac disease or arrhythmias should be closely monitored. Concomitant use may increase the risk for QT prolongation. Cimetidine is a known inhibitor of hepatic CYP enzymes. Minor Vardenafil is metabolized by cytochrome P 3A4. QT prolongation and ventricular arrhythmias including fatal torsade de pointes have also been reported with oxaliplatin use in postmarketing experience. Carbetapentane; Phenylephrine; Pyrilamine: Staxyn is a prescription medication used to treat erectile dysfunction impotence in adult men. Major Due to the potential for QT prolongation and torsade de pointes TdP , caution is advised when administering telavancin with vardenafil. When given together these agents may produce an additive reduction in blood pressure. Coadministration could lead to the risk of additive QT prolongation. We comply with the HONcode standard for trustworthy health information - verify here. Minor Tricyclic antidepressants TCAs share pharmacologic properties similar to the Dosage IA antiarrhythmic agents and may prolong staxyn QT interval, staxyn dosage, particularly in overdose or with higher-dose prescription therapy elevated serum concentrations.