Spedra (avanafil) Facts

Medicinal Products. Advertisement - Continue Reading Below. Avanafil avanafil extensively metabolised in humans. Pregnancy options discussion Advice and counselling What is abortion? Do not exceed the stated dose. For Spedra to wvanafil effective, sexual stimulation is required. In a clinical trial performed in healthy volunteers and adult males with mild erectile dysfunction, avanafil daily administration of avanafil mg oral doses over a period of 26 weeks was not associated with any untoward effects on sperm concentration, count, motility, or morphology. For these reasons, before you start taking avanafil it is important that your doctor knows:. From Wikipedia, spedra avanafil, the free encyclopedia. The nitric oxide stimulates an enzyme that produces something called a messenger cyclic guanosine monophosphate cGMP. Consequently, co-administration of avanafil with potent CYP3A4 inhibitors is contraindicated see sections 4. Pharmacy by Medicines Medicines. Sexual health Medicines Who sledra take mebeverine? Popular Treatments. It is recommended you have an interval of at least 2 days between each dose. Never take spedra than the spedra dose. April 27, Prescription only medicine. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately. This medicine is for you. Treatment delivered. Back pain Muscle tightness. It allows you to choose how your GP sends your prescriptions to the pharmacy. Avanafil is a PDE5 inhibitor.

Marketing authorisation holder 8. In the Time to onset study, avanafil demonstrated statistically significant improvement in the primary efficacy variable average per subject proportion of successful responses by time after dose administration, to the Sexual Encounter Profile 3 - SEP3 as compared with placebo, resulting in successful intercourse in Spedra juice should be avoided within 24 hours prior to taking Spedra. Pharmacodynamic effects Studies in vitro have shown that avanafil is highly selective for PDE5. Patients should be advised that concurrent use of avanafil and alcohol may increase the likelihood of hypotension, dizziness, or syncope. If you are worried about side effects, Viagra is a good choice. Annals of Pharmacotherapy. Avanafjl spedra by inhibiting a specific phosphodiesterase type 5 enzyme which is found in various body tissues, but primarily in the avanafil cavernosum spedra avanfil, as well as the retina. It is absorbed quickly, reaching a maximum concentration in about 30—45 minutes. If you find exact treatment cheaper elsewhere, avanafil will refund the difference. To understand how it works you need to understand the mechanics of how a man gets avanafil erection. Avanafil is not a problem for most men. Viagra is often prescribed as the first line treatment. For these reasons, before you start taking avanafil it is important that your doctor knows:. Disturbances of the gut such as diarrhoea, pain in the lower abdomen and dry mouth, spedra avanafil. Cyclic GMP is normally broken down by another chemical in the body called phosphodiesterase type 5. There was a statistically significant difference in maximum decrease from baseline in supine diastolic blood pressure with enalapril and avanafil only, which returned to baseline 4 hours after avanzfil dose of avanafil. These may be of use for men who have to take Nitrates and are therefore unable to take aavnafil PDE5 inhibitors. It is important to tell your doctor or pharmacist what spedra you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Spedra might not work the first time you take it. This is particularly true if ED develops as a result of a spinal injury or after abdominal or prostate surgery. Patients who demonstrate haemodynamic instability on alpha-blocker therapy alone are at increased risk of symptomatic hypotension with concomitant use of avanafil. With any medication you take, there is always a risk of side effects. Blood pressure increased Blood urine present Cardiac murmur Prostate specific antigen increased Weight increased Blood bilirubin increased Blood creatinine increased Body temperature increased.

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Men with uncontrolled high blood pressure hypertension. Concomitant use of alcohol Consumption of alcohol in combination with avanafil can increase the potential for symptomatic hypotension see section 4. What is it used for? Inflammation of the stomach gastritis. Other special populations Elderly Older patients 65 years or over had comparable exposure to that seen in younger patients years. Spedra works spedra inhibiting a specific phosphodiesterase type 5 enzyme which is found in various body tissues, but primarily in the corpus cavernosum penis, as well as the retina. If Spedra is taken with food, the onset of activity may be delayed compared to the fasted state see section 5. Description Spedra Avanafil mg 8 Tablets contains the active ingredient Avanafil. Find out more here. Immune system disorders. This results in smooth muscle relaxation and inflow of blood into the penile tissues, thereby producing an avanafil. Each tablet contains: At this stage it is hard to say which product has less side effects. Nitrates are one of the treatments doctors prescribe for angina. Your personal information will never be passed on to anyone other than our medical staff. Spedra will not resolve the underlying cause of erectile dysfunction although if the cause is primarily psychological, it may help to break the cycle of anxiety and failure associated with being unable to achieve a satisfactory erection. Reproductive system and breast disorders.

Viagra has been proven to be a safe and effective treatment for many years and is trusted by men across the world. Never avanaful it to other people even if their condition appears to be the same as yours. Co-administration of avanafil with potent CYP3A4 inhibitors including ketoconazole, ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir and telithromycin is contraindicated see sections 4. Spedrw navigation, spedra avanafil. Sign Up Log In Cancel. See also: Did you find this information useful? By using this site you agree to our use of cookies. If Spedra avanaifl used spedra combination with another medicinal product which reduces systemic blood pressure, the avanafil effects may result in symptomatic hypotension e. CYP3A4 Inhibitors Ketoconazole mg dailya selective and highly potent inhibitor of CYP3A4, increased avanafil 50 mg single-dose C max and exposure AUC equal to 3-fold and fold respectively and prolonged the half-life of avanafil to approximately 9 hours. Nitrates avanafil one of the treatments doctors prescribe for angina. Back in stock email notification for Spedra Avanafil mg 8 Tablets Sign up for updates below. Spedra was found effective for 60 percent of men view trial data for the highest strength treatment. Spedra works by inhibiting a specific phosphodiesterase type 5 enzyme which is found in various body tissues, but primarily in the corpus cavernosum penis, as well as the retina. Spedrs effects Medicines and their possible side effects can affect individual people in different ways. There was no evidence of favourable clinical effect of the combination in the population studied. This is not a problem for most men. For oral use. Spedra 50 mg tablets Spedra mg tablets Avajafil mg tablets. Xpedra data reveal no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, and toxicity spedra reproduction.

Spedra avanafil

Patient Information Dear customer, Further to the distressing news about personal patient information being sold to third parties, I wanted to reassure all visitors to the site that any details submitted to Oxford Online Pharmacy are treated as confidential - at all times. Blood in the urine. Namespaces Article Talk. The following list is not complete but it is important to inform the doctor of all prescription and non-prescription medication taken, especially: You should avoid drinking grapefruit juice in the 24 hours before taking this medicine, as it may increase the level of this medicine in your blood and so could increase the risk of side effects. If you are avanafil an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking. Spedra is one of a class of drugs known as PDE-5 Phosphodiesterase type 5 inhibitors. Men with conditions spedra as sickle cell disease, bone cancer or leukaemia in which there is an increased risk of prolonged erections priapism. Register today in three easy steps. Priligy dapoxetine. I have a prescription If you have a prescription for Spedra please add the correct amount of tablets to your basket. Details of where to send the prescription will be avanafil a unique order number at the confirmation page. Hypersensitivity to the active substance or avanafil any of the excipients listed in section 6. Spedra is claimed to act faster and to avanafil for four to six hours. Spedra is taken for the treatment of men with erectile dysfunction, this is the inability to achieve or maintain an erection sufficient for sexual performance. You can opt out at any time or find out more by reading our cookie policy. A spedra history and physical examination should be spedra to diagnose erectile dysfunction and determine potential underlying causes, spedra pharmacological treatment is considered. Detailed information on this medicinal product is available on the website of the European Medicines Agency http: Avanafil is a PDE5 inhibitor. Retrieved 17 April Studies in vitro have shown that avanafil is highly selective for PDE5. Each tablet contains 50 mg, spedra avanafil, mg or mg of avanafil. Ketoconazole mg dailya selective and highly potent inhibitor of CYP3A4, increased avanafil 50 mg single-dose C max and exposure AUC equal to 3-fold and fold respectively and prolonged the half-life of avanafil to approximately 9 hours. CYP3A4 Inhibitors Ketoconazole mg dailya selective and highly potent inhibitor of CYP3A4, increased avanafil 50 mg single-dose C max and exposure AUC equal to 3-fold and fold respectively and prolonged the half-life of avanafil to approximately 9 hours. Throughout all trials of Spedra, statistically significant improvements in all primary efficacy outcomes were observed for all three doses 50mg, mg and mg of avanafil compared with placebo.

Nasal congestion. The impact of avanafil on other transporters is unknown. Studies have shown that medicinal products that inhibit CYP3A4 can increase avanafil exposure see section 4. Both Spedra and Viagra last around four to six hours. Pharmacy2U are unable to prescribe this item through the Online Doctor service. Nitrate medications include the following:. This medicine is for you. Limited data are available in elder patients aged 70 years or above. Spedra is a treatment prescribed to adult men who suffer from Erectile Dysfunction more commonly known as impotence. Chest pain. Avanafil of erectile dysfunction in adult men. Sinus congestion and headache. If avanafil is taken by people who are taking medicines for high blood pressure antihypertensives avanafil, the combination may potentially cause an extra drop in blood pressure. This allows more blood to enter avanagil penis, which ultimately results in the penis becoming rigid and erect. Choose your treatment, spedra avanafil. If you have an erection that avanafil more than 4 hours, seek medical help spedra. Remember Spedra will only help you to get an erection if you are sexually stimulated. Haemodynamic interactions apedra doxazosin and tamsulosin were studied in healthy subjects in a two-period crossover-design sspedra. The co-administration of type 5 phosphodiesterase PDE5 spedra, including avanafil, with guanylate cyclase stimulators, such avannafil riociguat is contraindicated as it may potentially lead to symptomatic hypotension spedra section 4. Dated November avanafll Toggle navigation. Avanafil is for the treatment of adult men with erectile dysfunction. Further reading and references.

Never take more than the prescribed dose. Tabulated list of adverse reactions The table below lists the adverse reactions observed in placebo-controlled clinical trials according to the MedDRA frequency convention: Svanafil affect between 1 in and 1 in people Dizziness. Alpha-blockers include avanafil following: Patient Platform Limited has used all reasonable care in compiling the information but make no warranty as to its accuracy. Respiratory, thoracic and mediastinal spera. How it Works? Patients who are using potent CYP3A4 inhibitors including ketoconazole, ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir and telithromycin see sections 4. Choose your spedra. Throughout all trials of Spedra, statistically significant improvements in all primary efficacy outcomes were wpedra for all three doses 50mg, mg and mg avanafill avanafil compared with placebo. If you buy any medicines, check with a pharmacist that they are safe to take with your other medicines. One result of this is that the arteries in your penis dilate and the avanafil can spedra into your penis more easily. Start symptom checker. Visit our Online Doctor for a confidential consultation. You can opt out at any time or find out more by reading our cookie policy. Active ingredient avanafil. If Avanafil is avsnafil with food, the onset of activity may be delayed compared to the fasted state see section 5. Metabolism spedra nutrition disorders. Breast-feeding There are no data on the use of avanafil during breast-feeding. Interactive image, spedra avanafil.

Medicine Net. Mannitol Spedra acid Hydroxypropylcellulose Hydroxypropylcellulose, low substituted Calcium carbonate Magnesium stearate Yellow iron oxide E If you experience any other symptoms which you think may be due to the avaanfil, speak with your doctor or pharmacist for further advice. How did you xpedra about us? Men with a physical abnormality of the penis, such as severe curvature, scarring or Peyronie's disease. Some men may respond to a lower dose spdra Spedra. Increased heart rate tachycardia. Concomitant use of alcohol Consumption of alcohol in combination with avanafil can increase the potential for symptomatic hypotension see section 4. Other moderate CYP3A4 inhibitors e. Viagra Conclusion Viagra has been proven to be a safe avanafil effective treatment for many years and is trusted by men across the world. Keep spedra of the reach and sight of children, spedra avanafil. Tell your doctor if you have ever experienced this. Fertility There was no effect on sperm motility or morphology after single mg avanfail doses of avanafil in healthy volunteers. NuvaRing epedra, etonogestrel. Dear customer, Avanafil to the distressing news about personal patient information being sold to third parties, I wanted to reassure all visitors to the site that any details submitted to Oxford Online Pharmacy are treated as confidential - at all times. Pharmaceutical particulars 6. Avanafil should be used with caution in people who are taking alpha-blocker medicines, as the combination may increase the risk of a drop in blood pressure, which may cause dizziness or fainting. If the headaches continue, let your doctor know Flushing, blocked nose These should soon pass. CS1 maint: Cardiac disorders. Thanks for your feedback.

Archived from the original on Spedra is taken for the treatment of men with erectile dysfunction, this is the inability to achieve or maintain an erection sufficient for sexual performance. The nitric oxide stimulates an enzyme that produces something called a messenger cyclic guanosine monophosphate cGMP. Avanafil can be synthesized from a benzylamine derivative and a pyrimidine derivative: Adverse reactions were similar to those seen at lower doses but incidence rates and severities were increased. Mirena coil levonorgestrel. Decreased or sudden loss of hearing Patients should be advised to stop taking PDE5 inhibitors, including avanafil, and seek prompt medical attention in the event of sudden decrease or loss of hearing. As a vasodilator, avanafil may reduce systemic blood pressure. Avanafil is available on prescription, but it is only prescribed on the NHS for men with erectile dysfunction resulting from certain medical conditions. Patients who are using any form of organic nitrate or nitric oxide donors such as amyl nitrite see section 4. High blood pressure. Rare affect between 1 in and 1 in 10, people Inflammation of the nose and throat, causing a blocked or runny nose and sore throat nasopharyngitis. If you have a heart condition it is important that you discuss this with the doctor before taking Spedra. Men with an active peptic ulcer. Avanafil is rapidly absorbed after oral administration, with a median T max of 30 to 45 minutes. Dated November

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Pharmacodynamic effects Studies in vitro have shown that avanafil is highly selective for PDE5. Details of where to send the prescription will be given a unique order number at the confirmation page. How does Spedra work? SmPC Patient Leaflet. Cardiovascular status Prior to initiating any treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients since there is a degree of cardiac risk associated with sexual activity see section 4. Patients who are using any form of organic nitrate or nitric oxide donors such as amyl nitrite see section 4. If the headaches continue, let your doctor know Flushing, blocked nose These should soon pass. Drinking alcohol at the same time as taking Spedra may increase your heart rate and lower your blood pressure. Retrieved 28 September Patients were instructed to take 1 dose of study medicinal product approximately 30 minutes prior to initiation of sexual activity. Marketing authorisation number s 9. Back to top A. You can check the current price of all treatments using our treatment price finder. Millinette ethinylestradiol and gestodene. Date of revision of the text. Renal dialysis is not expected to accelerate clearance as avanafil is highly bound to plasma proteins and it is not eliminated in the urine. Ketoconazole mg daily , a selective and highly potent inhibitor of CYP3A4, increased avanafil 50 mg single-dose C max and exposure AUC equal to 3-fold and fold respectively and prolonged the half-life of avanafil to approximately 9 hours. It can be temporary or permanent. In clinical trials, avanafil was assessed for its effect on the ability of men with erectile dysfunction ED to achieve and maintain an erection sufficient for satisfactory sexual activity.

spedra avanafil

The concomitant use of potent CYP3A4 inhibitors e. Please inform your doctor or pharmacist if you have previously experienced such an allergy. This does not mean one has prolonged erections but the length of time available for further erections is increased without the need to take further doses. You can choose a safe place if you are not home to accept delivery or if they still can't deliver, a card will be left so you can arrange re-delivery for free. Limited data are available in elder patients aged 70 years or above. Choose your treatment. Special Offers. CYP3A4 Inhibitors Ketoconazole mg daily , a selective and highly potent inhibitor of CYP3A4, increased avanafil 50 mg single-dose C max and exposure AUC equal to 3-fold and fold respectively and prolonged the half-life of avanafil to approximately 9 hours. Erectile dysfunction impotence. Men with any obstruction of blood flow out of the heart, eg due to narrowing of the aorta aortic stenosis. By using this site you agree to our use of cookies. Search in title. For a full list of erectile dysfunction treatments visit our online pharmacy erectile dysfunction treatment page. Not all pack sizes may be marketed. Hair Loss. Older patients 65 years or over had comparable exposure to that seen in younger patients years. Nitrate medications include the following: Spedra is taken for the treatment of men with erectile dysfunction, this is the inability to achieve or maintain an erection sufficient for sexual performance. Your Prescription. Avanafil is a PDE5 inhibitor. This means that you can purchase products from us discreetly, such as weight loss, hair loss, STD or erectile dysfunction products. Urologicals; Drugs used in erectile dysfunction. Spedra starts to work in around 30 minutes and in some men it may work as quickly as 15 minutes! Blood in the urine. In humans, PDE5 inhibitors do not appear to affect bleeding time alone or in combination with acetylsalicylic acid. Other treatments for erectile dysfunction The safety and efficacy of combinations of avanafil and other PDE5 inhibitors or other treatments for erectile dysfunction have not been studied see section 4. Men with low blood pressure hypotension. Co-administration of avanafil with potent inhibitors of CYP3A4, such as ketoconazole or ritonavir is contraindicated see sections 4. Spedra is a treatment prescribed to adult men who suffer from Erectile Dysfunction more commonly known as impotence. Immune spedra disorders. Men with severely decreased kidney function. Therefore, avanafil avanafil be administered to such patients only after careful benefit-risk assessment. The table below contains some of spedra most common ones associated with avanafil. The recommended avanafil is mg tablet or as directed by your GP.

With nearly 1 in 2 UK households requiring an NHS repeat prescription, chances are you know somebody who could benefit from using Pharmacy2U See more info. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist. Pregnancy options discussion Advice and counselling What is abortion? The most common adverse reactions reported in clinical studies were headache, flushing, nasal and sinus congestion and back pain. Tell your doctor if you have ever experienced this. SmPC Patient Leaflet. Mechanism of action Avanafil is a highly selective and potent, reversible inhibitor of cyclic guanosine monophosphate cGMP -specific phosphodiesterase type 5. If avanafil is taken by people who are taking medicines for high blood pressure antihypertensives , the combination may potentially cause an extra drop in blood pressure. NuvaRing ethinylestradiol, etonogestrel. This results in smooth muscle relaxation and inflow of blood into the penile tissues, thereby producing an erection. Special Offers. All men who develop ED should see a doctor for a check-up. Muscle tightness. Close Submit Reminder. If you have any questions about this medicine ask your pharmacist. Avanafil should not be taken with other treatments for erectile dysfunction, as the safety of such combinations has not been established. Every member of our team is committed to delivering the best possible customer service so that you the can feel completely confident that you are getting the right advice and treatment for your needs, whether you are visiting us in one of our bricks and mortar pharmacies or you prefer to manage your healthcare needs online. Other treatments for erectile dysfunction The safety and efficacy of combinations of avanafil and other PDE5 inhibitors or other treatments for erectile dysfunction have not been studied see section 4. Alpha-blockers Haemodynamic interactions with doxazosin and tamsulosin were studied in healthy subjects in a two-period crossover-design trial. Viagra Conclusion Viagra has been proven to be a safe and effective treatment for many years and is trusted by men across the world. The maximum recommended dosing frequency is once per day. Men with hereditary degeneration of the back of the eyeball retinasuch as retinitis pigmentosa. The following list is not complete but it is important to inform the doctor of all prescription and non-prescription medication taken, especially: Side Effects of Spedra With any medication you take, there is always a risk of side spwdra. If you take Spedra after a large meal, it may take longer to become effective.