Cartia XT® (Diltiazem HCl Extended-Release Capsules, USP)
Diltiazem is an inhibitor of CYP3A4. Concomitant use warrants caution due to the potential catria increased side effects. Moderate Diltiazem could theoretically inhibit CYP3A4 metabolism of oxidized benzodiazepines, including chlordiazepoxide. This is cartia a list of all drugs or catria problems that interact with Cartia XT diltiazem long-acting capsules. Nanoparticle Albumin-Bound Paclitaxel: Intermittent hemodialysis Diltiazem is not significantly removed by hemodialysis. Nilotinib and diltiazeml are both substrates of and inhibitors of CYP3A4. The first dose response acute postural hypotension of prazosin may be exaggerated in patients who are receiving beta-adrenergic blockers, diuretics, or other antihypertensive agents. The recommended administration of diltiazem ER may vary depending on the individual product being used. Carbetapentane; Phenylephrine; Pyrilamine: They are the same drug, cartia xt, but they are not interchangeable. Read all information given to you. Coadministration of atorvastatin 40 mg with diltiazem mg was associated with a higher plasma concentration of atorvastatin. In general, titrate dosage at 1- to 2-week intervals. Clinicians should also note that calcium-channel blockers with CYP3A4 inhibitory properties, such as diltiazem, nicardipine, verapamil, may also reduce the hepatic metabolism of selected ergot alkaloids and increase the risk of ergot toxicity. If diltiazem is discontinued, oxycodone plasma concentrations will decrease resulting in reduced efficacy of the opioid and potential withdrawal syndrome in a patient who has developed physical dependence to oxycodone. Oxycodone is a CYP3A4 substrate, cartai coadministration with a moderate inhibitor like diltiazem can caetia oxycodone exposure resulting in increased or prolonged opioid effects including fatal respiratory depression, particularly when an inhibitor is added to a stable dose of oxycodone. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Diphenhydramine; Naproxen: Diltiazem is a substrate and inhibitor of the hepatic isoenzyme CYP3A4; isavuconazole, the active moiety of isavuconazonium, is a sensitive substrate and moderate cartia of CYP3A4. Severe The concomitant use of flibanserin and moderate CYP3A4 inhibitors, such as diltiazem, is contraindicated. NSAIDs cause a dose-dependent reduction in prostaglandin formation, which may result in a reduction in renal blood flow leading to renal cartia and an increase in blood pressure that are often accompanied by peripheral edema and weight cartia. Moderate The pharmacologic effects of isoproterenol may cause an increase in blood pressure. Lumacaftor; ivacaftor may reduce the efficacy of diltiazem by decreasing its systemic exposure. Subsequent bolus doses should be individualized.
Diltiazem is a substrate of CYP3A4. Moderate The combination of diltiazem and a beta-blocker, like carteolol, is usually well tolerated; the combination is often used for their combined therapeutic benefits to reduce angina and improve exercise tolerance. Major The cardiovascular effects of sympathomimetics, such as ephedrine, may reduce the antihypertensive effects produced by calcium-channel blockers. Major Use caution if coadministration cartka dronabinol with diltiazem is necessary, and monitor for an increase in dronabinol-related adverse reactions e. This additive effect can be desirable, but the patient should be monitored carefully and the dosage should be adjusted based on clinical response. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a cratia bad side effect:. Major The potential for hypotension may be increased when coadministering nesiritide with antihypertensive agents. Moderate Diltiazem could theoretically inhibit CYP3A4 metabolism of oxidized benzodiazepines, such as flurazepam. Loperamide; Simethicone: Dihydrocodeine; Guaifenesin; Pseudoephedrine: Hawthorn, Crataegus laevigata: Severe The concomitant use of flibanserin and moderate CYP3A4 inhibitors, such as diltiazem, is contraindicated. Dorzolamide; Timolol: Moderate Monitor for an cartia in sildenafil-related adverse reactions if coadministration with diltiazem is cargia a dose reduction of sildenafil may be necessary when prescribed for acrtia dysfunction. All drugs may cause side effects. If diltiazem is discontinued, oxycodone plasma concentrations will decrease resulting in reduced efficacy of the opioid and potential dartia syndrome in a patient who has developed physical dependence to oxycodone. Oxycodone is a CYP3A4 substrate, and coadministration with a moderate inhibitor like diltiazem can increase oxycodone exposure resulting in increased or prolonged opioid effects including fatal respiratory depression, particularly when an inhibitor is added to a stable dose of oxycodone. Side effects in more detail. Some people with a slow heart beat are completely healthy, for example athletes tend to have a slower heart rate. Patients taking antihypertensive agents may need to have their therapy modified. However, in clinical trials with alprostadil intracavernous fartia, anti-hypertensive agents had no apparent effect on the safety and efficacy of alprostadil. Systemic drug interactions with the urethral suppository MUSE or alprostadil intracavernous carta are unlikely in most patients because low or undetectable amounts of the drug are found in the peripheral carita circulation following administration.
The OBRA guidelines also caution that antiarrhythmic agents can have serious adverse effects e. Call your doctor for medical advice about cartia effects. Major Avoid coadministration of diltiazem and rifampin due to decreased plasma concentrations of diltiazem. According to the manufacturer of diltiazem Cardizemthe most common side effects reported are dizziness, headache, cough, feeling tired, slowing of the heart crtia, and swelling of the legs cartia edema. Major If diltiazem and ivacaftor are taken together, administer ivacaftor at the usual recommended dose but reduce the frequency to once daily. The capsule may be administered by opening the capsule and sprinkling the capsule contents onto a spoonful of applesauce. Acetaminophen; Dextromethorphan; X Chlophedianol; Dexchlorpheniramine; Pseudoephedrine: Acetaminophen; Dichloralphenazone; Isometheptene: Aldesleukin, IL This interaction may increase the potential for dofetilide-induced cartia. Coadministration with another strong CYP3A4 inducer lowered diltiazem plasma concentrations to undetectable. After discontinuing cisapride, the QT interval returned to normal without recurrence of symptoms. Major Avoid coadministration of diltiazem and apalutamide due to decreased plasma concentrations of diltiazem. Cetirizine; Pseudoephedrine: However, the effect of prescription drugs on body weight is complex. Co-administration with diltiazem may lead to an increase in serum levels of drugs that are CYP3A4 substrates, such as cabergoline. Monitor for lidocaine toxicity if used together. Generic Name: Stable for up to 60 cartia when stored at 5 degrees C or 25 degrees C room temperature. If these drugs are co-administered, dose adjustment of repaglinide may be necessary.
Cartia interaction is presumed due to increased simvastatin bioavailability via inhibition of CYP3A4 metabolism by diltiazem. The OBRA guidelines also caution that antiarrhythmic agents can have serious adverse effects e. Moderate Diltiazem is a CYP3A4 inhibitor caryia may reduce the carria of estazolam and increase the potential for benzodiazepine toxicity. Cetirizine; Pseudoephedrine: In addition, bosentan may induce hepatic metabolism of calcium-channel blockers metabolized by CYP3A4 isoenzymes. Concurrent use may significantly increase concentrations of desDFZ, the active metabolite of deflazacort, resulting in an increased risk of toxicity. After 15 minutes, a second bolus dose of 0. The AAP also considers verapamil, another calcium-channel blocker, to be usually compatible with breast-feeding. Moderate Additive hypotensive effects cartia occur with the concomitant administration of diazoxide with other antihypertensive agents. Patients should be monitored for efficacy and toxicity. Desloratadine; Pseudoephedrine: Moderate Concomitant use of dihydrocodeine with diltiazem may increase dihydrocodeine plasma concentrations, resulting in greater metabolism by CYP2D6, increased dihydromorphine concentrations, and prolonged opioid adverse reactions, including hypotension, respiratory depression, profound sedation, coma, and death. Empagliflozin; Metformin: Dextromethorphan; Diphenhydramine; Phenylephrine: Diltiazem mg-MYL, white, oblong, film coated.
Diltiazem is an inhibitor of this enzyme and may decrease the clearance of mefloquine and increase mefloquine systemic exposure. Moderate Diltiazem is a CYP3A4 inhibitor and may reduce the metabolism of estazolam and increase the potential for benzodiazepine toxicity. Monitor plasma PTH and serum cartia and phosphorous concentrations if a patient initiates or discontinues therapy with this combination. Clinically significant interactions have been reported when doxorubicin was coadministered with inhibitors of CYP3A4, resulting in increased concentration and clinical effect of tx. Therefore, drugs known to prolong the PR interval, such as diltiazem, cartia xt, should be avoided in cartia taking dolasetron. Major Avoid coadministration of ceritinib with diltiazem due to increased diltiazem exposure and the xartia of additive bradycardia. Loperamide; Simethicone: Carbetapentane; Diphenhydramine; Phenylephrine: Subsequent dosage adjustments should be based on clinical response. Specific dosage adjustment recommendations are available for the Colcrys product for patients who have taken diltiazem in the past 14 days or require concurrent use: Continuous IV therapy should not be administered for longer than 24 hours. Cetirizine; Pseudoephedrine: Concomitant use may result in elevated plasma concentrations of dronabinol. However, as a single mg intravenous dose, fosaprepitant only weakly inhibits CYP3A4 for a duration of 2 days; there is no evidence of CYP3A4 induction. Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir:
Moderate Concomitant administration of dexmedetomidine and calcium-channel blockers could lead to additive hypotension and bradycardia; use together with caution. The metabolism of progesterone is inhibited by ketoconazole, a known inhibitor of cytochrome P 3A4 hepatic enzymes. This interaction is likely due to the combined inhibition of CYP3A by erythromycin and the calcium channel blockers leading cartia increases in the serum concentrations of erythromycin and the calcium channel blockers. Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine: Dosage adjustments of the antihypertensive medication may be required. In addition, the presence of medications in the circulation that attenuate erectile function may influence the response to alprostadil. Diltiazem 60 mg-MYL, yellow, round, film coated. You may also report side effects at http: Diltiazem is excreted in human cartia. This additive effect can be desirable, but the patient should be monitored carefully and the cxrtia should be adjusted based on clinical response. Moderate Risperidone has been associated with orthostatic hypotension and may enhance the hypotensive effects of antihypertensive agents. Tiazac or generic equivalent Taztia XT extended-release capsules 24 hours: Ethinyl Estradiol; Norelgestromin: Concomitant use of diltiazem, a CYP3A4 inhibitor, and dihydroergotamine, a CYP3A4 substrate with a narrow therapeutic range, may result in carfia ergot alkaloid levels. Major Coadministration of atazanavir with diltiazem may result in increased plasma concentrations of either drug. Bosentan has been shown to have no pharmacokinetic interactions with nimodipine. Carbetapentane; Phenylephrine: Cetirizine; Pseudoephedrine: Lumacaftor; ivacaftor may reduce the efficacy of diltiazem by decreasing its systemic exposure.
Moderate Monitor for an increased incidence of etoposide-related adverse effects if used concomitantly with diltiazem. Minor Saxagliptin did not meaningfully alter the pharmacokinetics of diltiazem. Moderate The combination of diltiazem and a beta-blocker, like nebivolol, is usually well tolerated; the combination is often used for their combined therapeutic benefits to reduce angina and improve exercise tolerance. Major Coadministration of diltiazem and moricizine may increase both moricizine and diltiazem plasma concentrations. Lansoprazole; Naproxen: Based on the pharmacology of conivaptan, there is also potential for additive hypotensive effects when coadministered with calcium-channel blockers. Major Diethylpropion has vasopressor effects and may limit the benefit of calcium-channel blockers. If diltiazem is discontinued, allow 7 days to elapse before increasing the lapatinib dose. The metabolism of progesterone is inhibited by ketoconazole, a known inhibitor of cytochrome P 3A4 hepatic enzymes. These are not all of the side effects that may occur. If a moderate CYP3A4 inhibitor is added to an existing lurasidone regimen, reduce the lurasidone dose to one-half of the original dose. As diltiazem is both a substrate and an inhibitor of CYP3A4, monitor patients for corticosteroid-related side effects if prednisolone and diltiazem are taken. Amoxicillin; Clarithromycin; Lansoprazole: Major Avoid concomitant use of diltiazem with neratinib due to an increased risk of neratinib-related toxicity. Periodic evaluation of blood pressure is advisable during concurrent use of dexmethylphenidate and antihypertensive agents, particularly during initial coadministration and after dosage increases of dexmethylphenidate. Available for Android and iOS devices. Consider a cariprazine dose reduction if hypotension occurs. Common side effects with diltiazem are hypotension abnormally low blood pressure , bradycardia abnormally low heart beat , headache, fatigue, weakness, drowsiness, constipation or diarrhea, nausea, vomiting, facial flushing, and difficulty sleeping.
What do I need to tell my doctor BEFORE I take Cartia XT?
Subscribe to receive email notifications whenever new articles are published. Product Detail. Coadministration with diltiazem increased naloxegol exposure by approximately 3. Concomitant use of diltiazem, a CYP3A4 inhibitor, and ergotamine, a CYP3A4 substrate with a narrow therapeutic range, may result in increased ergot alkaloid levels. Chlordiazepoxide; Clidinium: Dextromethorphan; Guaifenesin; Phenylephrine: Further, in patients with cardiogenic shock, intravenous diltiazem is contraindicated. Avoid use in patients with pre-excitation, left ventricular systolic dysfunction, or decompensated heart failure. Coadministration may result in increased rilpivirine plasma concentrations. Ethinyl Estradiol; Ethynodiol Diacetate: Ethinyl Estradiol; Desogestrel: Moderate Fish oil supplements may cause mild, dose-dependent reductions in systolic or diastolic blood pressure in untreated hypertensive patients. Hydrocodone; Pseudoephedrine: Clinical practice guidelines for cardiopulmonary resuscitation and emergency cardiovascular care also suggest a nondihydropyridine calcium channel blocker for PSVT if adenosine or vagal maneuvers fail to convert, if PSVT recurs after these therapies, or if these therapies disclose another SVT. CoQ10 use in combination with antihypertensive agents may lead to additional reductions in blood pressure in some individuals. Atazanavir; Cobicistat: Saxagliptin dose adjustment is not advised when coadministered with diltiazem. Dihydrocodeine; Guaifenesin; Pseudoephedrine: Diltiazem is an inhibitor of the hepatic isoenzyme CYP3A4; rilpivirine is metabolized by this isoenzyme. Do not significantly increase grapefruit juice intake while taking diltiazem, or avoid grapefruit juice if possible. This is not a list of all drugs or health problems that interact with Cartia XT diltiazem long-acting capsules. Azithromycin may be preferred if the use of a macrolide antibiotic is necessary in a patient receiving calcium-channel blocker therapy.
This slow heart beat can cause fatigue and other symptoms. Some patients may respond to an initial bolus dose of 0. Coadministration of eliglustat with CYP3A inhibitors, such as diltiazem, may increase eliglustat exposure and the risk of serious adverse events e. CoQ10 use in combination with antihypertensive agents may lead to additional reductions in blood pressure in some individuals. These patients may require additional monitoring and information. Cardizem LA mg, white, oblong,. Major The potential for hypotension may be increased when coadministering nesiritide with antihypertensive agents. Estradiol; Levonorgestrel: Moderate Care should be taken when dosing paricalcitol with strong CYP3A4 inhibitors, such as diltiazem. Coadministration of atorvastatin 40 mg with diltiazem mg was associated with a higher plasma concentration of atorvastatin. Brimonidine; Timolol: These are not all of the side effects that may occur. Do not significantly increase grapefruit juice intake while taking diltiazem, or avoid grapefruit juice if possible. Subscribe to receive email notifications whenever new articles are published. Acetaminophen; Hydrocodone: Diltiazem should be used with caution in patients with mild to moderate hypotension. Inhibition of methadone metabolism can lead to toxicity including CNS adverse effects and potential for QT prolongation and torsades de pointes when high doses of methadone are used e. High Blood Pressure Hypertension. Minor Diltiazem may increase plasma concentrations of oral budesonide due to inhibition of the CYP3A4 isoenzymet, and can enhance the cortisol suppression associated with budesonide administered via inhalation. Coadministration may result in increased acalabrutinib exposure and toxicity e. Bupivacaine Liposomal: Brimonidine; Timolol: Perindopril; Amlodipine: BasicDescription Back to Top. Acetaminophen; Pseudoephedrine: This represents a pharmacodynamic, and not a pharmacokinetic, interaction. Systemic drug interactions with the urethral suppository MUSE or alprostadil intracavernous injection are unlikely in most patients because low or undetectable amounts of the drug are found cartia the peripheral venous circulation following administration. Isoniazid, INH; Rifampin: Moderate Use caution and careful monitoring when coadministering cartia with calcium-channel blockers; efavirenz induces CYP3A4, potentially altering serum concentrations of drugs metabolized by this enzyme such as some calcium-channel blockers. If these drugs are co-administered, dose adjustment of repaglinide may be necessary.
Diltiazem 90 mg-WAT, blue, oblong,. Cobicistat; Elvitegravir; Emtricitabine; Tenofovir Alafenamide: Major Alfuzosin and diltiazem may have additive vasodilatory actions; concurrent use of these agents can result in hypotension. Lumacaftor is a strong CYP3A inducer. To find out if your medication is available as a Teva generic, contact your local pharmacy. The dosage range studied in clinical trials was to mg. For patients with breast cancer, neuroendocrine tumors, renal cell carcinoma, and renal angiolipoma with tubular sclerosis complex TSC , reduce the dose of Afinitor to 2. However, many people have no side effects or only have minor side effects. Ethinyl Estradiol; Norgestrel: Fluoxetine; Olanzapine: Major Avoid concomitant use of bosutinib and diltiazem as bosutinib plasma exposure may be significantly increased resulting in an increased risk of bosutinib adverse events e. Moderate Current data suggest that grapefruit juice has a limited effect on diltiazem bioavailability. Refer to our editorial policy for content sources and attributions. Artemether; Lumefantrine: Home Product Detail print. Diltiazem is contraindicated in patients with acute myocardial infarction and pulmonary congestion and should not be used in patients with acute myocardial infarction and associated left ventricular dysfunction or congestive heart failure. Estradiol Cypionate; Medroxyprogesterone: Side effects in more detail. Moderate Although no specific interactions have been documented, bosentan has vasodilatory effects and may contribute additive hypotensive effects when given with calcium-channel blockers. Coadministration with diltiazem is predicted to increase the relative potency adjusted unbound AUC of abemaciclib plus its active metabolites M2, M18, and M20 by approximately 2. Dorzolamide; Timolol: NSAIDs cause a dose-dependent reduction in prostaglandin formation, which may result in a reduction in renal blood flow leading to renal insufficiency and an increase in blood pressure that are often accompanied by peripheral edema and weight gain. General anesthetics: Coadministration has been associated with an increased risk of hypotension and shock. Xg am 75 years old and I have been on diltiazem mg for one year. Close observation and monitoring of blood glucose is necessary to acrtia adequate glycemic control. Coadministration of atorvastatin 40 mg carita diltiazem mg was associated with a higher plasma concentration of atorvastatin. Some patients respond to lower doses e. Patients with SSS with a functioning artificial ventricular pacemaker may use still use a calcium channel blocker. Ginkgo, cartia xt, Ginkgo biloba: In addition, bosentan may cartia hepatic metabolism of calcium-channel blockers metabolized by CYP3A4 isoenzymes. Although leading drug interaction texts differ in the potential for an interaction between diethylpropion and this group of antihypertensive agents, these effects are likely to be clinically significant and have been described in hypertensive patients on these medications.